Tretinoin vs. Retinol (vs. Bakuchiol): How do they work and compare?

WRITTEN BY Devanshi Garg Sareen
Tretinoin vs. Retinol (vs. Bakuchiol): How do they work and compare?

In the ever-evolving world of skincare, one ingredient family stands tall as the gold standard for anti-aging - retinoids. 

 

Backed by decades of rigorous scientific research and even FDA-approved for specific anti-aging benefits, retinoids have proven to be unmatched in their efficacy.

 

But with great power comes great responsibility—retinoids, while effective, may not suit everyone. Enter bakuchiol, a plant-based retinoid-alternative with anti-aging benefits similar to retinol with greater tolerance (minus the irritation potential). 


As we age, our skin undergoes natural changes: collagen production slows, cell turnover decreases, and environmental damage accumulates, manifesting as fine lines, wrinkles, uneven tone, and loss of elasticity. These changes, compounded by oxidative stress and reduced hydration, can make skin appear dull and aged.

 

 

For anyone embarking on their skincare journey, choosing the right ingredient—be it the proven efficacy of retinoids or the gentle promise of bakuchiol—is a daunting but crucial decision. These ingredients are known to combat signs of aging through varied mechanisms such as antioxidant properties, collagen regeneration, and exfoliation resulting in the coveted youthful glow.


So how do you pick which one is right for you? Let’s break down the differences between these three evidence-backed skincare heavyweights to help you make the right choice.

 

What does Retinol do?


Let us review the essentials of what retinoids are, how they work, and how the natural, retinol mimicking substance - bakuchiol differs from them - 


Retinoids: 

These are a class of compounds derived from Vitamin A, known for their ability to improve skin texture, fight acne, and reduce the appearance of fine lines and wrinkles.


Retinoids are fat-soluble molecules that penetrate the skin's upper layers and prevent collagen degradation. Retinoids also regulate the shedding of dead skin cells, helping in skin rejuvenation and improving skin texture. Additionally, topical formulations of retinoids also act on melanocytes, the pigment-containing cells to even out the distribution of melanin in the skin. This helps reduce pigmentation. 


However, this multimodal action comes at a price. Retinoids are known to cause a “purge” including skin dryness, redness, peeling, stinging, sun sensitivity, and in severe cases even blistering if used incorrectly.

 

Irritation caused by retinoids damages the skin barrier making it drier and interfering with the skin's ability to repair itself. Chronic skin inflammation due to irritation can also trigger the breakdown of collagen and elastin, hastening skin aging. Most importantly, retinoid side effects can discourage consistent use of the product, preventing the active ingredient from exerting its full effect.


Note: Retinoids may not be suitable for everyone and must be used after consulting a dermatologist. 

 

 

Although there are many different molecules within the retinoid family, Tretinoin and Retinol are two of the most commonly used ones. Let’s understand how different retinoids differ from one another.


  1. Tretinoin: A prescription-strength, synthetic form of retinoid that is potent and fast-acting. It is most commonly used to treat acne and reduce signs of aging
  2. Retinol: A milder, over-the-counter form of Vitamin A that can also promote skin cell turnover, but with a slower, more gradual effect compared to Tretinoin. It is the easiest to access and the preferred option for beginners just introducing retinoids in their routine.
  3. Retinal: Retinal or Retinaldehyde is a direct precursor of Retinoic acid and requires only one step for conversion. As a result, it is converted to the active ingredient Retinoic acid 11 times faster than Retinol while retaining the same side effect profile.


Note: Bakuchiol: A plant-derived ingredient often referred to as a natural alternative to retinoids. It’s gaining popularity due to its gentler nature and anti-aging benefits without the irritation typically associated with retinoids. 

 

Bakuchiol stimulates collagen synthesis, has potent antioxidant and anti-inflammatory properties, and promotes skin cell turnover.

 

Even with these retinol-mimicking mechanisms, Bakuchiol has much better tolerance and a significantly milder side effect profile making it a favored option for beginners and for those whom the dreaded retinol purge is just not an option.

 

How long does Retinol take to work: skin benefits and potential side effects


Each of these ingredients brings something unique to the table when it comes to improving skin health in the short and long term.


 

Tretinoin 

Renowned for its fast and noticeable results being the most bioactive topical retinoid. It quickly accelerates skin cell turnover, helps clear acne, reduces fine lines, and improves skin texture. However, its potency means it can be drying and irritating for many. Studies show that dermatitis, called the “purge” or the “retinoid skin reaction” is the most common adverse effect experienced by those using 0.01-0.05% tretinoin. The sandwich method of application is advised in which a moisturizer is layered before and after tretinoin application reducing its strength. 


Tretinoin use requires a prescription of a qualified dermatologist and it should only be applied in the strength and frequency prescribed.


Retinol

A more gentle option that still delivers results over time. It is effective in promoting cell turnover, reducing fine lines, and tackling mild acne. It is converted to retinoic acid in a two-step oxidation process to exert these effects. It may take a little longer to see results, but it’s a safer option for most skin types.

 

A study comparing three strengths of retinol (0.25%, 0.5%, and 1.0%) with three strengths of tretinoin (0.025%, 0.05%, and 0.1%) found both of them to be equally effective in reducing signs of photodamage. These included overall photodamage, fine lines and wrinkles, skin tone, brightness, mottled pigmentation, and tactile roughness of the skin. Retinol is commercially available in concentrations ranging from 0.0015% and 0.3%. Side effects of retinol are similar to those with tretinoin but are typically milder. These can be mitigated by introducing products at a lower concentration only once or twice a week initially and then increasing the frequency of application based on tolerance.


Bakuchiol

Often considered a more skin-friendly alternative to retinoids. It offers similar benefits, including improved skin texture, reduced fine lines, and acne treatment, but with minimal irritation. Bakuchiol is especially beneficial for people with sensitive skin who want the anti-aging effects of retinoids without dryness or peeling. Bakuchiol has also been combined with retinal to potentiate its effects with significant improvement in skin elasticity, firmness, and texture within 28 days of nightly use. The Motif Power Brightening Bicelle Serum combines 1% Bakuchiol with other clinically backed actives including Licorice Root, Azelaic Acid and Niacinamide in a non-irritating, glow-inducing, hydrating formulation.


Safety and Usage During Pregnancy and Lactation

 

For women, the safety of skincare products during pregnancy and lactation is an important concern -


  • Tretinoin should be avoided during pregnancy and breastfeeding due to its potential teratogenic effects. However, there is not enough conclusive evidence regarding the absorption of tretinoin into the bloodstream after applying it to the skin. 
  • Retinol, especially in higher concentrations, should also be used with caution during pregnancy. However, lower doses might be safe if used intermittently in the later part of pregnancy. 
  • Bakuchiol, on the other hand, is safe to use during pregnancy and lactation. It is non-teratogenic and poses no known risks to pregnant or breastfeeding women.


A Quick Comparison: Tretinoin, Retinol, and Bakuchiol

 

*It is important to note that using sunscreen is a pivotal part of any antiaging skincare routine as photodamage contributes up to 90% to the aging process.  Combining powerful actives with daily sunscreen use, and controlling for irritation, is the key to maintaining healthy, youthful skin and protecting it from long-term damage.

 

Where you can start with your Retinoids...


While Tretinoin and Retinol are tried-and-tested ingredients for anti-aging and acne treatment with varying degrees of tolerance, Bakuchiol offers a gentler, plant-based alternative that’s just as effective but with far superior tolerance. It’s especially suitable for those with sensitive skin or those looking for a more sustainable option for long-term use. Your skin regimen is incomplete unless it includes at least one of these ingredients.

 

Previous Article Next Article
Keep Reading
1